Accueil>>Lipids>> Octadecanoids>>13(S)-HODE

13(S)-HODE (Synonyms: 13(S)-HODE)

Catalog No.GC19463

13(S)-HODE (13(S)-HODE), le produit du métabolisme de la 15-lipoxygénase (15-LOX) de l'acide linoléique, fonctionne comme le ligand endogène pour activer PPARγ.

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13(S)-HODE Chemical Structure

Cas No.: 29623-28-7

Taille Prix Stock Qté
25µg
82,00 $US
En stock
50µg
131,00 $US
En stock
100µg
179,00 $US
En stock
250µg
405,00 $US
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,[1],[2] and down regulates the expression of the IRGpIIb/IIIa receptor.[3]

Reference:

[1]. Buchanan, M.R., Haas, T.A., Lagarde, M., et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX The Journal of Biological Chemisty 260, 16056-16059 (1985).
[2]. Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis Prostaglandins 44(5), 413-429 (1992).
[3]. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid Cancer Res. 49(4), 1029-1037 (1989).

Chemical Properties

Cas No. 29623-28-7 SDF
Synonymes 13(S)-HODE
Chemical Name 13S-hydroxy-9Z,11E-octadecadienoic acid
Canonical SMILES CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
Formula C18H32O3 M.Wt 296.5
Solubility DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3727 mL 16.8634 mL 33.7268 mL
5 mM 0.6745 mL 3.3727 mL 6.7454 mL
10 mM 0.3373 mL 1.6863 mL 3.3727 mL
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