Accueil>>16-phenoxy tetranor Prostaglandin F2α methyl amide

16-phenoxy tetranor Prostaglandin F2α methyl amide (Synonyms: 16phenoxy tetranor PGF2α methyl amide)

Catalog No.GC41949

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.

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16-phenoxy tetranor Prostaglandin F2α methyl amide Chemical Structure

Taille Prix Stock Qté
500μg
74,00 $US
En stock
1mg
140,00 $US
En stock
5mg
589,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor PGF2α is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl amide is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

Chemical Properties

Cas No. SDF
Synonymes 16phenoxy tetranor PGF2α methyl amide
Canonical SMILES O[C@@H]1[C@H](C/C=C\CCCC(NC)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC=C2)[C@H](O)C1
Formula C23H33NO5 M.Wt 403.5
Solubility DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): .5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.4783 mL 12.3916 mL 24.7831 mL
5 mM 0.4957 mL 2.4783 mL 4.9566 mL
10 mM 0.2478 mL 1.2392 mL 2.4783 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for 16-phenoxy tetranor Prostaglandin F2α methyl amide

Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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