Accueil>>Signaling Pathways>> Membrane Transporter/Ion Channel>>(±)-Nornicotine-d4

(±)-Nornicotine-d4 (Synonyms: DL-Nornicotine-d4, (R,S)-Nornicotine-d4)

Catalog No.GC49482

An internal standard for the quantification of (±)-nornicotine

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(±)-Nornicotine-d4 Chemical Structure

Cas No.: 66148-18-3

Taille Prix Stock Qté
1 mg
43,00 $US
En stock
5 mg
195,00 $US
En stock
10 mg
334,00 $US
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-Nornicotine-d4 is intended for use as an internal standard for the quantification of (±)-nornicotine by GC- or LC-MS. (±)-Nornicotine is an active metabolite of nicotine and a nicotinic acetylcholine receptor (nAChR) agonist.1 It induces currents in Xenopus oocytes expressing human α7 nAChRs or α6 subunit-containing nAChRs (EC50s = 17 and 3.7 µM, respectively). (±)-Nornicotine promotes cell migration and destabilizes cell-cell junctions in EA.hy926 endothelial cells.2 It is self-administered in rats.3,4

1.Papke, R.L., Dwoskin, L.P., and Crooks, P.A.The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: Relevance to nicotine dependence and drug discoveryJ. Neurochem.101(1)160-167(2007) 2.Gagat, M., Grzanka, D., Izdebska, M., et al.Nornicotine impairs endothelial cell-cell adherens junction complexes in EA.hy926 cell line via structural reorganization of F-actinFolia Histochem. Cytobiol.51(3)179-192(2013) 3.Bardo, M.T., Green, T.A., Crooks, P.A., et al.Nornicotine is self-administered intravenously by ratsPsychopharmacology (Berl)146(3)290-296(1999) 4.Hoffman, A.C., and Evans, S.E.Abuse potential of non-nicotine tobacco smoke components: Acetaldehyde, nornicotine, cotinine, and anabasineNicotine Tob. Res.15(3)622-632(2013)

Chemical Properties

Cas No. 66148-18-3 SDF Download SDF
Synonymes DL-Nornicotine-d4, (R,S)-Nornicotine-d4
Canonical SMILES [2H]C1=NC([2H])=C(C2NCCC2)C([2H])=C1[2H]
Formula C9H8D4N2 M.Wt 152.2
Solubility Methanol: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.5703 mL 32.8515 mL 65.703 mL
5 mM 1.3141 mL 6.5703 mL 13.1406 mL
10 mM 0.657 mL 3.2852 mL 6.5703 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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