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18β-Glycyrrhetyl-3-O-sulfate

Catalog No.GC71042

18β-Glycyrrhetyl-3-O-sulfate (acide glycyrrhizoïque 3 - O - (sulfate d'hydrogène)) est un puissant inhibiteur de la 11β - hydroxystéroïde déshydrogénase (11β - hsd2) de type 2 avec une CI50 de 0,10 µm en utilisant des microsomes rénaux de rat.

Products are for research use only. Not for human use. We do not sell to patients.

18β-Glycyrrhetyl-3-O-sulfate Chemical Structure

Cas No.: 10251-38-4

Taille Prix Stock Qté
1 mg
139,00 $US
En stock
5 mg
306,00 $US
En stock
10 mg
486,00 $US
En stock

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

Description of 18β-Glycyrrhetyl-3-O-sulfate

18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)) is a potent type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) inhibitor with an IC50 of 0.10 µM using rat kidney microsome. 18β-Glycyrrhetyl-3-O-sulfate is the major metabolite of Glycyrrhetinic acid (GA). 18β-Glycyrrhetyl-3-O-sulfate is the substrate of organic anion transporter (OAT) 1 and OAT3. 18β-Glycyrrhetyl-3-O-sulfate has anti-inflammatory effects and has the potential for pseudohyperaldosteronism research.

Chemical Properties of 18β-Glycyrrhetyl-3-O-sulfate

Cas No. 10251-38-4 SDF
Formula C30H46O7S M.Wt 550.75
Solubility DMSO : 100 mg/mL (181.57 mM; Need ultrasonic) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 18β-Glycyrrhetyl-3-O-sulfate

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.8157 mL 9.0785 mL 18.1571 mL
5 mM 363.1 μL 1.8157 mL 3.6314 mL
10 mM 181.6 μL 907.9 μL 1.8157 mL
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In vivo Formulation Calculator (Clear solution) of 18β-Glycyrrhetyl-3-O-sulfate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for 18β-Glycyrrhetyl-3-O-sulfate

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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