2'-Deoxy-L-adenosine |
| Catalog No.GC67328 |
2'-Deoxy-L-adénosine est un synthon actif par voie orale pour les oligodésoxyribonucléotides modifiés. 2'-La désoxy-L-adénosine est un inhibiteur puissant, spécifique et sélectif de la réplication du virus de l'hépatite B (VHB) ainsi que des virus de l'hépatite du canard et de la marmotte (WHV).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14365-45-8
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].
2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].
2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].
[1]. Standring DN, et al. Antiviral beta-L-nucleosides specific for hepatitis B virus infection. Antivir Chem Chemother. 2001;12 Suppl 1:119-29.
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