2-Keto Crizotinib (PF-06260182) |
| Catalog No.GC33319 |
Le 2-céto crizotinib (PF-06260182) (PF-06260182) est un métabolite lactame actif du crizotinib.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1415558-82-5
Sample solution is provided at 25 µL, 10mM.
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2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.
[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.
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