3,6-DMAD hydrochloride |
Catalog No.GC34384 |
Le chlorhydrate de 3,6-DMAD, un dérivé de l'acridine, est un puissant inhibiteur de la voie IRE1α-XBP1s. Le chlorhydrate de 3,6-DMAD favorise la sécrétion d'IL-6 via la voie IRE1α-XBP1s. Le chlorhydrate de 3,6-DMAD inhibe l'oligomérisation de l'IRE1α et l'activité de l'endoribonucléase (RNase). Le chlorhydrate de 3,6-DMAD peut être utilisé pour la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.
3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity[1].
Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth[1].
[1]. Jiang D, et al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65.
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