(32-Carbonyl)-RMC-5552 |
| Catalog No.GC63524 |
(32-Carbonyl)-RMC-5552 est un puissant inhibiteur de mTOR. (32-Carbonyl)-RMC-5552 inhibe la phosphorylation des substrats mTORC1 et mTORC2 (p-P70S6K-(T389), p-4E-BP1-(T37/36), ET p-AKT1/2/3-(S473)) avec des pIC50 > 9, > 9 et entre 8 et 9, respectivement (brevet WO2019212990A1, exemple 2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2382768-55-8
Sample solution is provided at 25 µL, 10mM.
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(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].
[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.
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