5'-chloro-5'-Deoxyadenosine (hydrate) (Synonyms: 5’-ClDA, 5'-Deoxy-5'-chloroadenosine) |
| Catalog No.GC18826 |
5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 698999-09-6
Sample solution is provided at 25 µL, 10mM.
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5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica.
References:
[1]1. Eustáquio, A.S., McGlinchey, R.P., Liu, Y., et al. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine Proc. Natl. Acad. Sci. USA 106(30), 12295-12300 (2009).
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