653-47 hydrochloride |
Catalog No.GC62144 |
Le chlorhydrate de 653-47, un potentialisateur, potentialise de manière significative l'activité inhibitrice de la protéine de liaison À l'élément de réponse À l'AMPc (CREB) de 666-15. Le chlorhydrate de 653-47 est également un très faible inhibiteur de CREB avec une IC50 de 26,3 μM.
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Cas No.: 1224567-46-7
Sample solution is provided at 25 µL, 10mM.
653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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