653-47 |
| Catalog No.GC62279 |
653-47, un potentialisateur, potentialise significativement l'activité inhibitrice de la protéine de liaison À l'élément de réponse À l'AMPc (CREB) de 666-15. Le 653-47 est également un inhibiteur CREB très faible avec une IC50 de 26,3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1224678-75-4
Sample solution is provided at 25 µL, 10mM.
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653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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