7,8-Dihydroxyflavone (Synonyms: 7,8-DHF) |
| Catalog No.GC16853 |
La 7,8-dihydroxyflavone est un agoniste puissant et sélectif de TrkB qui imite les actions physiologiques du facteur neurotrophique dérivé du cerveau (BDNF).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38183-03-8
Sample solution is provided at 25 µL, 10mM.
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7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1].
7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
References:
[1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39(3):638-50.
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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