α-CEHC (Synonyms: γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman) |
| Catalog No.GC11123 |
A major metabolite of δ-tocopherol
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Cas No.: 4072-32-6
Sample solution is provided at 25 µL, 10mM.
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Molecules having vitamin E antioxidant activity include four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ). α-Tocopherol is the major lipid soluble antioxidant in vivo and protects against lipid peroxidation. α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation. The concentration of α-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-α-tocopherol. About one-third of the α-CEHC circulating in the blood is present as a glucuronide conjugate. α-CEHC was only excreted when a threshold concentration of 7-9 µmol α-tocopherol/g total lipid in plasma was exceeded. Therefore, excretion of α-CEHC may be considered to be a marker of optimum vitamin E intake.
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