α-Ketoglutaric Acid (sodium salt) (Synonyms: α-KGA, 2-Oxoglutaric Acid) |
| Catalog No.GC48948 |
α-L'acide cétoglutarique (sel de sodium) (acide alpha-cétoglutarique de sodium) est un intermédiaire dans la production d'ATP ou de GTP dans le cycle de Krebs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22202-68-2
Sample solution is provided at 25 µL, 10mM.
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α-Ketoglutaric acid is an α-keto acid and a rate-determining metabolic intermediate in the citric acid cycle in its conjugate base form, α-ketoglutarate.1,2 It is formed via oxidative decarboxylation of isocitrate by isocitrate dehydrogenase (IDH), oxidative deamination of glutamate by glutamate dehydrogenase, or by pyridoxal phosphate-dependent transamination.2 α-Ketoglutaric acid is decarboxylated to succinyl-CoA by α-ketoglutarate dehydrogenase, a rate limiting step in the citric acid cycle. It is a precursor of glutamine and glutamate, energy sources for enterocytes and various immune cells, and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development.2,3
1.Krebs, H.A., Salvin, E., and Johnson, W.A.The formation of citric and α-ketoglutaric acids in the mammalian bodyBiochem. J.32(1)113-117(1938) 2.Wu, N., Yang, M., Gaur, U., et al.Alpha-ketoglutarate: Physiological functions and applicationsBiomol. Ther. (Seoul)24(1)1-8(2016) 3.Liu, S., He, L., and Yao, K.The antioxidative function of alpha-ketoglutarate and its applicationsBiomed. Res. Int.3408467(2018)
| Cas No. | 22202-68-2 | SDF | |
| Synonymes | α-KGA, 2-Oxoglutaric Acid | ||
| Canonical SMILES | O=C(C(CCC(O)=O)=O)O.[Na] | ||
| Formula | C5H5NaO5 | M.Wt | 168.08 |
| Solubility | DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.9495 mL | 29.7477 mL | 59.4955 mL |
| 5 mM | 1.1899 mL | 5.9495 mL | 11.8991 mL |
| 10 mM | 0.595 mL | 2.9748 mL | 5.9495 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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