σ1 Receptor antagonist-1 |
| Catalog No.GC62708 |
σ1 L'antagoniste des récepteurs-1 est un antagoniste des récepteurs sigma 1 très puissant et sélectif (pKi = 10,28).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1204401-49-9
Sample solution is provided at 25 µL, 10mM.
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σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1].
σ1 Receptor antagonist-1 (compound 9) (10 μM; 48 hours) inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1].
Pretreatment withσ1 Receptor antagonist-1 (1 mg/kg; s.c.) significantly increases the anti-nociceptive effect produces by morphine over the entire time course starting at 60 min[1].
[1]. Piergentili A, et al. Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem. 2010;53(3):1261-1269.
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