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(+)-Aeroplysinin-1 (Synonyms: NSC 170364)

Catalog No.GC18516

(+)-Aeroplysinin-1 ((+)-Aeroplysinin-1), un métabolite secondaire isolé des éponges marines, montre de puissants effets antibiotiques sur les bactéries Gram-positives et exerce une activité antivirale contre le VIH-1 (IC50 \u003d 14,6 μM).

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(+)-Aeroplysinin-1 Chemical Structure

Cas No.: 28656-91-9

Taille Prix Stock Qté
100μg
163,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Chemical Properties

Cas No. 28656-91-9 SDF
Synonymes NSC 170364
Chemical Name (1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile
Canonical SMILES COC1=C(Br)[C@H](O)[C@@](CC#N)(O)C=C1Br
Formula C9H9Br2NO3 M.Wt 339
Solubility Methanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9499 mL 14.7493 mL 29.4985 mL
5 mM 0.59 mL 2.9499 mL 5.8997 mL
10 mM 0.295 mL 1.4749 mL 2.9499 mL
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Review for (+)-Aeroplysinin-1

Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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