AICAR phosphate |
Catalog No.GC10580 |
AICAR phosphate (Acadesine phosphate) est un analogue de l'adénosine et un activateur de l'AMPK. Le phosphate AICAR régule le métabolisme du glucose et des lipides et inhibe la production de cytokines pro-inflammatoires et d'iNOS. Le phosphate AICAR est également un inhibiteur de l'autophagie, du YAP et de la mitophagie.
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Cas No.: 681006-28-0
Sample solution is provided at 25 µL, 10mM.
AICAR phosphate (Acadesine)is an activator of AMPK [1].
AICAR phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the EC50 value is 380±60μM on the viability assay of B-CLL cells. In addition, AICAR phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in B-CLL cells. Furthermore, AICAR phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate AMPK. Apart from these, AICAR phosphate (2-4 mM) has shown to only slightly affects the viability of T cells from B-CLL patients, AICAR phosphate (0.5 mM) has been noted to remarkedly reduces viability of B cells but not T cells [1].
References:
[1] Campàs C1, Lopez JM, Santidrián AF, Barragán M, Bellosillo B, Colomer D, Gil J. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003 May 1;101(9):3674-80. Epub 2003 Jan 9.
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