AKT-IN-6 |
| Catalog No.GC62190 |
AKT-IN-6 (exemple 13) est un puissant inhibiteur d'Akt. AKT-IN-6 inhibe Akt1, Akt2 et Akt3 avec des IC50 < 500 nM, respectivement. (brevet WO2013056015A1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1430056-54-4
Sample solution is provided at 25 µL, 10mM.
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AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].
[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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