Alborixin |
| Catalog No.GC91660 |
Alborixin is an ionophore originally isolated from S. albus that has diverse biological activities.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 57760-36-8
Sample solution is provided at 25 µL, 10mM.
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Alborixin is an ionophore originally isolated from S. albus that has diverse biological activities.1,2,3,4 It is active against B. cereus, B. megaterium, S. lactis, S. aureus, and C. xerosis (MIC50s = 0.4, <0.1, 0.8, 0.2, 0.8 mg/kg, respectively).[1] Alborixin decreases the proliferation of eight cancer cell lines (IC50s = 3.2 to 15.4 µM).[2] It induces apoptosis, decreases the mitochondrial membrane potential, and increases the levels of reactive oxygen species (ROS) in HCT116 colon cancer cells when used at a concentration of 5 µM. Alborixin (1 mg/kg) increases heart rate, right ventricular contractile force, systolic and diastolic arterial blood pressure, and plasma levels of glucose in the coronary sinus and hepatic veins, as well as decreases the QT interval and plasma levels of potassium and sodium, but not calcium, in the coronary sinus and hepatic, renal, and deep femoral veins in normotensive dogs.[3] It reduces the number of C. parvum oocytes in C. parvum-infected mice when administered at doses of 1.5 or 2.5 mg/kg.[4] Alborixin is toxic to mice (LD50 = 150 mg/kg).[1]
References:
[1].Delhomme, C., Kergomard, A., Kergomard, G., et al.Alborixin, a new antibiotic ionophore: Taxonomy, isolation and biological propertiesJ. Antibiot. (Tokyo)29(7)692-695(1976).
[2].Shah, A.M., Wani, A., Qazi, P.H., et al.Isolation and characterization of alborixin from Streptomyces scabrisporus: A potent cytotoxic agent against human colon (HCT-116) cancer cellsChem. Biol. Interact.256198-208(2016).
[3].Moins, N., Gachon, P., and Duchene-Marullaz, P.Effects of two monocarboxylic ionophores, grisorixin and alborixin, on cardiovascular function and plasma cation concentrations in the anesthetized dogJ. Cardiovasc. Pharmacol.1(6)659-671(1979).
[4].Blagburn, B.L., Sundermann, C.A., Lindsay, D.S., et al.Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss mice by polyether ionophores and aromatic amidinesAntimicrob. Agents Chemother.35(7)1520-1523(1991).
| Cas No. | 57760-36-8 | SDF | |
| Formula | C48H84O14 | M.Wt | 885.2 |
| Solubility | Dichloromethane: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1297 mL | 5.6484 mL | 11.2969 mL |
| 5 mM | 225.9 μL | 1.1297 mL | 2.2594 mL |
| 10 mM | 113 μL | 564.8 μL | 1.1297 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >70.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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