ALLO-2 |
| Catalog No.GC34463 |
ALLO-2 est un puissant antagoniste mutant Smoothened (Smo) résistant aux médicaments qui inhibe l'expression de la luciférase induite par l'agoniste Smo Hh-Ag1.5 dans les cellules TM3-Gli-Luc avec une IC50 de 6 nM.
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Cas No.: 1357350-60-7
Sample solution is provided at 25 µL, 10mM.
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ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM[1]. IC50: Smo[1].
[1]. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.
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