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AMG 853 (Synonyms: AMG 853)

Catalog No.GC50240

AMG 853 (AMG 853) est un dérivé de l'acide phénylacétique.

Products are for research use only. Not for human use. We do not sell to patients.

AMG 853 Chemical Structure

Cas No.: 1169483-24-2

Taille Prix Stock Qté
10 mg
259,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.

Liu et al (2011) Discovery of AMG 853, a CRTH2 and DP dual antagonist. ACS Med.Chem.Lett. 2 326 PMID:24900313

Chemical Properties

Cas No. 1169483-24-2 SDF
Synonymes AMG 853
Canonical SMILES ClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O
Formula C28H27Cl2FN2O6S M.Wt 609.49
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6407 mL 8.2036 mL 16.4072 mL
5 mM 0.3281 mL 1.6407 mL 3.2814 mL
10 mM 0.1641 mL 0.8204 mL 1.6407 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for AMG 853

Average Rating: 5 ★★★★★ (Based on Reviews and 26 reference(s) in Google Scholar.)

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