Arctigenin |
| Catalog No.GN10063 |
Arctigenin, un composé lignanique naturel, a démontré des activités anticancéreuses dans le cancer. Arctigenin présente de puissantes activités antioxydantes, anti-inflammatoires et antivirales (virus de la grippe A).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7770-78-7
Sample solution is provided at 25 µL, 10mM.
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Arctigenin, un composé lignanique naturel, a démontré des activités anticancéreuses dans le cancer. Arctigenin présente de puissantes activités antioxydantes, anti-inflammatoires et antivirales (virus de la grippe A)[3,4].
Arctigenin (40 µM;48h) a inhibé la croissance des cellules U87MG et T98G, induit l'arrêt du cycle cellulaire G0/G1 et déclenché l'apoptose cellulaire dans les cellules de gliome[1]. Arctigenin (10,20,40,80 et 100μmol/L;48h) possède une activité antitumorale dans les cellules T24 du cancer de la vessie. Au niveau moléculaire, Arctigenin a été capable de réduire l'expression de la cycline D1 et du phospho-ERK1/2, mais d'induire les niveaux de phospho-p38[4]. Arctigenin (0,1,56,12,5,100 μM ; 24h) induit l'apoptose dans les cellules HCC via les voies apoptotiques dépendantes des mitochondries et de Fas/FasL[5].
Arctigenin (25 mg/kg;ip ; deux fois par jour) pendant 23 jours a augmenté la phosphorylation AKT stimulée par l'insuline dans le muscle gastrocnémien et le foie, mais pas dans la graisse périnéale[2]. Arctigenin (50mg/kg/jour;ip) pendant 4 jours confère une protection contre les lésions inflammatoires et oxydatives pulmonaires induites par le LPS [6].
References:
[1]. Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A, Li W. Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells. Oncol Lett. 2017 Feb;13(2):1007-1013
[2]. Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD, Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia. 2012 May;55(5):1469-81.
[3]. Hayashi K, Narutaki K, Nagaoka Y, Hayashi T, Uesato S. Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus. Biol Pharm Bull. 2010;33(7):1199-205.
[4]. Yang S, Ma J, Xiao J, Lv X, Li X, Yang H, Liu Y, Feng S, Zhang Y. Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis. Anat Rec (Hoboken). 2012 Aug;295(8):1260-6.
[5]. Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015 May 1;10(5):e0125727.
[6]. Zhang WZ, Jiang ZK, He BX, Liu XB. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling. Inflammation. 2015 Aug;38(4):1406-14.
| Expériences cellulaires [1]: | |
Lignées cellulaires | Lignées cellulaires de gliome humain U87MG et T98G |
Méthode de préparation | Les lignées cellulaires de gliome humain U87MG et T98G ont été traitées avec de l'Actigénine ( 1-40μM ) pendant 48 h. |
Conditions de réaction | Actigenin ( 1-40μM ) ;48 h |
Domaines d'application | Arctigenin inhibe de manière dose-dépendante la croissance des cellules U87MG et T98G. |
| Expériences animales [2]: | |
Modèles animaux | Souris femelles ob/ob modèle |
Méthode de préparation | Des souris ob/ob femelles ont reçu d'Arctigenin (25 mg/kg;ip ; deux fois par jour) pendant 22 jours. |
Forme de dosage | Arctigenin (200 mg/kg q2d);23 jours;ip. |
Domaines d'application | Arctigenin (25 mg/kg;ip;deux fois par jour) a augmenté la phosphorylation de l'AKT stimulée par l'insuline dans le muscle gastrocnémien et le foie, mais pas dans la graisse périnéale. |
Références : | |
| Cas No. | 7770-78-7 | SDF | |
| Chemical Name | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | ||
| Canonical SMILES | COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC | ||
| Formula | C21H24O6 | M.Wt | 372.41 |
| Solubility | ≥ 17.2mg/mL in DMSO | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6852 mL | 13.4261 mL | 26.8521 mL |
| 5 mM | 0.537 mL | 2.6852 mL | 5.3704 mL |
| 10 mM | 0.2685 mL | 1.3426 mL | 2.6852 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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