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ATPγS tetralithium salt (Synonyms: ATPγS)

Catalog No.GC12574

ATPγS (sel tétralithium) est un substrat pour les activités d'hydrolyse des nucléotides et de déroulement de l'ARN du facteur d'initiation de la traduction eucaryote eIF4A.

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ATPγS tetralithium salt Chemical Structure

Cas No.: 93839-89-5

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1mg
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5mg
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10mg
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Sample solution is provided at 25 µL, 10mM.

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Background

L'adénosine 5'-(γ-thio)-triphosphate (sel de lithium) est un analogue stable de l'ATP qui agit comme un puissant agoniste des récepteurs couplés aux protéines G P2Y2 et P2Y11 (pEC50 = 5,52 pour P2Y11).[1] Il a été utilisé pour identifier les substrats de kinase, a été mis en œuvre en tant que réactif dans la synthèse d'analogues d'acétylglucosamine d'ADN et peut servir de substrat pour les activités d'hydrolyse nucléotidique stimulée par l'ARN et de déroulement de l'ARN du facteur d'initiation eucaryote-4A.[2],[3],[4]

References:
[1]. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
[2]. Knowles, J.R. Enzyme-catalyzed phosphoryl transfer reactions. Annual Reviews of Biochemistry 49, 877-919 (1980).
[3]. Chrysogelos, S., Register, J.C., III, and Griffith, J. The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). The Journal of Biological Chemisty 258(20), 12624-12631 (1983).
[4]. Peck, M.L., and Herschlag, D. Adenosine 5'-O-(3-thio)triphosphate (ATPγS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9(10), 1180-1187 (2003).

Chemical Properties

Cas No. 93839-89-5 SDF
Synonymes ATPγS
Chemical Name P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt
Canonical SMILES S=P([O-])([O-])O[P@](O[P@](OC[C@H]1O[C@@H]([C@@H]([C@@H]1O)O)N2C3=NC=NC(N)=C3N=C2)([O-])=O)([O-])=O.[Li+].[Li+].[Li+].[Li+]
Formula C10H12Li4N5O12P3S M.Wt 546.98
Solubility 10mg/mL in PBS, pH 7.2 Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.8282 mL 9.1411 mL 18.2822 mL
5 mM 0.3656 mL 1.8282 mL 3.6564 mL
10 mM 0.1828 mL 0.9141 mL 1.8282 mL
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