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B-Raf IN 2

Catalog No.GC64550

B-Raf IN 2 est un inhibiteur de BRAF puissant et sélectif extrait du brevet WO2021116055A1, composé Ia. B-Raf IN 2 peut être utilisé pour la recherche sur le cancer.

Products are for research use only. Not for human use. We do not sell to patients.

B-Raf IN 2 Chemical Structure

Cas No.: 2649372-20-1

Taille Prix Stock Qté
5 mg
234,00 $US
En stock
10 mg
378,00 $US
En stock
25 mg
756,00 $US
En stock
50 mg
1 215,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer[1].

B-Raf IN 2 shows considerably less paradoxial activation of the MAPK signaling pathway while retaining high potency[1].

[1]. Dolente C, et, al. New methylquinazolinone derivatives. WO2021116055A1.

Chemical Properties

Cas No. 2649372-20-1 SDF Download SDF
Formula C20H17F2N5O4S M.Wt 461.44
Solubility Storage 4°C, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1671 mL 10.8356 mL 21.6713 mL
5 mM 0.4334 mL 2.1671 mL 4.3343 mL
10 mM 0.2167 mL 1.0836 mL 2.1671 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for B-Raf IN 2

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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