BIO-013077-01 |
| Catalog No.GC62868 |
BIO-013077-01 est un inhibiteur du pyrazole TGF-β.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 746667-48-1
Sample solution is provided at 25 µL, 10mM.
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BIO-013077-01 is a pyrazole TGF-β inhibitor[1].
A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].
[1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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