BLU-945 |
| Catalog No.GC63910 |
Le BLU-945 est un inhibiteur de la tyrosine kinase (TKI) du récepteur du facteur de croissance épidermique (EGFR) puissant, hautement sélectif, réversible et actif par voie orale. Le BLU-945 peut inhiber efficacement l'EGFR avec la mutation par délétion L858R et/ou exon 19, la mutation T790M et la mutation C797S. Le BLU-945 peut être utilisé pour la recherche sur le cancer du poumon, y compris le cancer du poumon non À petites cellules (NSCLC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2660250-10-0
Sample solution is provided at 25 µL, 10mM.
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receptor (EGFR). EGFR is a member of the erbB receptor family, which includes transmembrane protein tyrosine kinase receptors. BLU-945 effectively inhibits EGFR with L858R and/or exon 19 deletion mutation, T790M mutation, and C797S mutation. BLU-945 facilitates efficacious dosing and reduces EGFR-mediated on-target toxicities. S BLU-945 has the potential for the research of cancer disease (extracted from patent WO2021133809A1, compound 112)[1].
[1]. John Emmerson Campbell, et al. Inhibitors of mutant forms of egfr. Patent WO2021133809A1.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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