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Bosutinib-d8 (Synonyms: SKI-606 D8)

Catalog No.GC40080

Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS.

Products are for research use only. Not for human use. We do not sell to patients.

Bosutinib-d8 Chemical Structure

Taille Prix Stock Qté
500μg
122,00 $US
En stock
1mg
230,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS. Bosutinib is an inhibitor of c-Src and Abl kinases (IC50s = 1.2 and 1 nM, respectively). It also inhibits the kinases EPHB2, TrkA, TrkB, and TXK (IC50s = 8.5, 22, 27, and 40 nM, respectively) among others. Bosutinib inhibits Src-dependent cell proliferation (IC50 = 100 nM) and reverses Src-transformed fibroblasts to a non-transformed morphology when used at a concentration of 1 µM. It reduces tumor growth in unstaged and staged Src-transformed fibroblast mouse xenograft models when administered at doses of 30 or 25 mg/kg, respectively, twice per day. Bosutinib (100 mg/kg) also induces complete tumor regression in a K562 mouse xenograft model when administered once per day for five days.

Chemical Properties

Cas No. SDF
Synonymes SKI-606 D8
Canonical SMILES CN1C([2H])([2H])C([2H])([2H])N(CCCOC2=C(OC)C=C(C(NC3=CC(OC)=C(Cl)C=C3Cl)=C(C#N)C=N4)C4=C2)C([2H])([2H])C1([2H])[2H]
Formula C26H21Cl2D8N5O3 M.Wt 538.5
Solubility DMSO: Slightly Soluble,Methanol: Slightly Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.857 mL 9.2851 mL 18.5701 mL
5 mM 0.3714 mL 1.857 mL 3.714 mL
10 mM 0.1857 mL 0.9285 mL 1.857 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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