C-1 |
| Catalog No.GC11605 |
C-1 est un puissant inhibiteur de la protéine kinase, avec des IC50 de 4 μM, 8 μM, 12 μM et 240 μM pour la protéine kinase dépendante de la cGMP (PKG), la protéine kinase dépendante de l'AMPc (KA). , la protéine kinase C (PKC) et la MLC-kinase, respectivement. C-1 également utilisé comme inhibiteur de ROCK.
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Cas No.: 84468-24-6
Sample solution is provided at 25 µL, 10mM.
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HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively[1].
HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, and the Ki values are 61 and 6.5 μM, respectively[1].
References:
[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.
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