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Cafestol

Catalog No.GC40352

Cafestol, l'un des principaux composants du café, est un diterpène spécifique au café.

Products are for research use only. Not for human use. We do not sell to patients.

Cafestol Chemical Structure

Cas No.: 469-83-0

Taille Prix Stock Qté
5mg
58,00 $US
En stock
10mg
84,00 $US
En stock
50mg
250,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].

References:
[1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32.

Chemical Properties

Cas No. 469-83-0 SDF
Canonical SMILES O[C@]1(CO)C[C@]23[C@](CC[C@]1([H])C3)([H])[C@@](CCC4=C5C=CO4)(C)[C@]5([H])CC2
Formula C20H28O3 M.Wt 316.4
Solubility DMF: 12 mg/ml,DMF:PBS (pH 7.2) (1:50): 0.02 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.1606 mL 15.8028 mL 31.6056 mL
5 mM 0.6321 mL 3.1606 mL 6.3211 mL
10 mM 0.3161 mL 1.5803 mL 3.1606 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for Cafestol

Average Rating: 5 ★★★★★ (Based on Reviews and 27 reference(s) in Google Scholar.)

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