Calcium D-Panthotenate |
| Catalog No.GC15161 |
Le D-panthoténate de calcium (sel de calcium de la vitamine B5), une vitamine, peut réduire la teneur en patuline du jus de pomme.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137-08-6
Sample solution is provided at 25 µL, 10mM.
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Target: N/A
IC50: N/A
Calcium D-Panthotenate, also named vitamin B5 Calcium, is a water-soluble vitamin for many animals [1, 2]. Pantothenic acid participates in a number of intermediary metabolic reactions as a component of coenzyme A (CoA). It has been reported that pantothenic acid exhibits radioprotective and antioxidative effects and pantothenic acid has the potential to protect against cell damage produced by reactive oxygen species [3].
In vitro: Pantothenic acid (1 mM) increased biosynthesis of glutathione by boosting cell energetic in Jurkat cells [3]. In addition, pantothenic acid (1 mM) protected against oxidative damage and apoptosis in Ehrlich ascites tumour cells [4].
In vivo: Pantothenic acid (200 mg/kg, intraperitoneal injections) completely blocked valproic acid-induced neural tube defects and the decreases in c-Myb and Pim-1 protein expression in CD-1 mice [1]. Moreover, Calcium D-pantothenate (3.39-10.54 mg/kg, diets) increased the intestinal enzymes activities and docosahexaenoic acid (DHA) levels [2].
References:
1. Dawson JE, Raymond AM, Winn LM. Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol Appl Pharmacol. 2006;211(2):124-32.
2. Qian Y, Li XF, Zhang DD, Cai DS, Tian HY, Liu WB. Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala. PLoS One. 2015;10(3):e0119518.
3. Slyshenkov VS, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569(1-3):169-72.
4. Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. Biofactors. 2003;17(1-4):61-73.
| Cas No. | 137-08-6 | SDF | |
| Canonical SMILES | CC(CO)([C@](O)([H])/C([O-])=N/CCC([O-])=O)C.CC(CO)([C@](O)([H])/C(O)=N/CCC(O)=O)C.[Ca+2] | ||
| Formula | C18H32CaN2O10 | M.Wt | 476.53 |
| Solubility | DMSO : 44mg/mL; Water : 44mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0985 mL | 10.4925 mL | 20.985 mL |
| 5 mM | 419.7 μL | 2.0985 mL | 4.197 mL |
| 10 mM | 209.9 μL | 1.0493 mL | 2.0985 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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