(S)-DO271 |
| Catalog No.GC46352 |
An inactive control for DO264
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2301865-01-8
Sample solution is provided at 25 µL, 10mM.
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(S)-DO271 is an inactive control for the α/β-hydrolase domain-containing protein 12 (ABHD12) inhibitor DO264 .1,2 Unlike DO264, (S)-DO271 does not inhibit ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates when used at a concentration of 1 µM or modify inflammatory cytokine production in M1-polarized THP-1 macrophages.
1.Ogasawara, D., Ichu, T.-A., Vartabedian, V.F., et al.Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivoNat. Chem. Biol.14(12)1099-1108(2018) 2.Ogasawara, D., Ichu, T.-A., Jing, H., et al.Discovery and optimization of selective and in vivo active inhibitors of the lysophosphatidylserine lipase α/β-hydrolase domain-containing 12 (ABHD12)J. Med. Chem.62(3)1643-1656(2019)
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