2-(1,8-Naphthyridin-2-yl)phenol (Synonyms: 2-NP) |
| Catalog No.GC46503 |
Le 2-(1,8-naphtyridin-2-yl)phénol est un activateur sélectif de la transcription de STAT1. Le 2-(1,8-naphtyridin-2-yl)phénol peut améliorer la capacité de l'IFN-γ ; pour inhiber la prolifération des cellules humaines du cancer du sein et du fibrosarcome.
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Cas No.: 65182-56-1
Sample solution is provided at 25 µL, 10mM.
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2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity.1 It enhances IFN-γ-induced STAT1-dependent signaling, but not IFN-γ-induced STAT3-dependent signaling or TNF-α-induced NF-κB-dependent signaling in cell-based reporter assays when used at a concentration of 45 µM. 2-NP (45 µM) increases IFN-γ-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at the same concentration.
1.Lynch, R.A., Etchin, J., Battle, T.E., et al.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cellsCancer Res.67(3)1254-1261(2007)
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