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2',2'-Difluoro-2'-deoxyuridine (Synonyms: dFdU)

Catalog No.GC46508

An active metabolite of gemcitabine

Products are for research use only. Not for human use. We do not sell to patients.

2',2'-Difluoro-2'-deoxyuridine Chemical Structure

Cas No.: 114248-23-6

Taille Prix Stock Qté
1 mg
67,00 $US
En stock
5 mg
201,00 $US
En stock
10 mg
369,00 $US
En stock
25 mg
752,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine .1 It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It enhances radiation-induced cell death of ECV304 and NCI H292 cells when used at concentrations ranging from 10 to 100 µM.2

1.Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al.New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridineMol. Cancer Ther.7(8)2415-2425(2008) 2.Pauwels, B., Korst, A.E.C., Lambrechts, H.A.J., et al.The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitroCancer Chemother. Pharmacol.58(2)219-228(2006)

Chemical Properties

Cas No. 114248-23-6 SDF
Synonymes dFdU
Canonical SMILES O=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O
Formula C9H10F2N2O5 M.Wt 264.2
Solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.785 mL 18.9251 mL 37.8501 mL
5 mM 0.757 mL 3.785 mL 7.57 mL
10 mM 0.3785 mL 1.8925 mL 3.785 mL
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Review for 2',2'-Difluoro-2'-deoxyuridine

Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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