Accueil>>Signaling Pathways>> Ox Stress Reagents>>3,3',5-Triiodo-L-thyronine (sodium salt hydrate)

3,3',5-Triiodo-L-thyronine (sodium salt hydrate) (Synonyms: Liothyronine, T3, L3,3',5Triiodothyronine)

Catalog No.GC48395

3,3',5-Triiodo-L-thyronine (sel de sodium hydraté) est une forme active de l'hormone thyroÏdienne.

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3,3',5-Triiodo-L-thyronine (sodium salt hydrate) Chemical Structure

Cas No.: 345957-19-9

Taille Prix Stock Qté
100mg
60,00 $US
En stock
250mg
127,00 $US
En stock
500mg
165,00 $US
En stock
1g
301,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone.1 It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling.2,3,4,5 It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 µM.6

1.Larsen, P.R., Silva, J.E., and Kaplan, M.M.Relationships between circulating and intracellular thyroid hormones: Physiological and clinical implicationsEndocr. Rev.2(1)87-102(1981) 2.Shiohara, H., Nakamura, T., Kikuchi, N., et al.Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemiaBioorgan. Med. Chem.20(11)3622-3634(2012) 3.Cox, M.D., Dalal, S.S., Heard, C.R.C., et al.Metabolic rate and thyroid status in rats fed diets of different protein-energy value: The importance of free T3J. Nutri.114(9)1609-1616(1984) 4.Macchia, P.E., Takeuchi, Y., Kawai, T., et al.Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor αProc. Nat. Acad. Sci. U.S.A.98(1)349-354(2001) 5.Videla, L.A., Cornejo, P., Romanque, P., et al.Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioningSci. World J.20121-11(2012) 6.Kongpracha, P., Nagamori, S., Wiriyasermkul, P., et al.Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)J. Pharmacol. Sci.133(2)96-102(2017)

Chemical Properties

Cas No. 345957-19-9 SDF
Synonymes Liothyronine, T3, L3,3',5Triiodothyronine
Canonical SMILES IC1=C(OC2=CC(I)=C(O)C=C2)C(I)=CC(C[C@@H](C([O-])=O)N)=C1.[Na+].O
Formula C15H11I3NO4•Na [XH2O] M.Wt 673
Solubility DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml Storage Store at -20°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4859 mL 7.4294 mL 14.8588 mL
5 mM 0.2972 mL 1.4859 mL 2.9718 mL
10 mM 0.1486 mL 0.7429 mL 1.4859 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 1 reference(s) in Google Scholar.)

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