1(R)-(Trifluoromethyl)oleyl alcohol |
| Catalog No.GC49034 |
An oleic acid analog
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1 It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 µM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 µM) reduces lipid peroxidation induced by FXN siRNA knockdown in NBT human myoblasts.
1.Cotticelli, M.G., Forestieri, R., Xia, S., et al.Identification of a novel oleic acid analog with protective effects in multiple cellular models of Friedreich ataxiaACS Chem. Neurosci.11(17)2535-2542(2020)
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