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2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline (Synonyms: MeIQx)

Catalog No.GC49362

A food-derived carcinogen

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2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline Chemical Structure

Cas No.: 77500-04-0

Taille Prix Stock Qté
5 mg
94,00 $US
En stock
10 mg
180,00 $US
En stock
25 mg
401,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1 It is activated by hydroxylation and subsequent O-acetylation via the cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2 MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

1.Johansson, M.A., and JÄgerstad, M.Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditionsCarcinogenesis15(8)1511-1518(1994) 2.Metry, K.J., Neale, J.R., Doll, M.A., et al.Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx)Mutat. Res.684(1-2)66-73(2010) 3.Kushida, H., Wakabayashi, K., Sato, H., et al.Dose-response study of MeIQx carcinogenicity in F344 male ratsCancer Lett.83(1-2)31-35(1994)

Chemical Properties

Cas No. 77500-04-0 SDF
Synonymes MeIQx
Canonical SMILES NC(N1C)=NC2=C1C=CC3=NC=C(C)N=C32
Formula C11H11N5 M.Wt 213.2
Solubility DMSO: slightly soluble,Methanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.6904 mL 23.4522 mL 46.9043 mL
5 mM 0.9381 mL 4.6904 mL 9.3809 mL
10 mM 0.469 mL 2.3452 mL 4.6904 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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