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CAY10561 (Synonyms: Pyrazolylpyrrole ERK Inhibitor)

Catalog No.GC43167

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.

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CAY10561 Chemical Structure

Cas No.: 933786-58-4

Taille Prix Stock Qté
500μg
34,00 $US
En stock
1mg
66,00 $US
En stock
5mg
274,00 $US
En stock
10mg
479,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.

Chemical Properties

Cas No. 933786-58-4 SDF
Synonymes Pyrazolylpyrrole ERK Inhibitor
Canonical SMILES [H]N1C(C2=CNC(C(NC(CO)C3=CC=C(F)C(Cl)=C3)=O)=C2)=C(C4=CC(Cl)=CC=C4)C=N1
Formula C22H17Cl2FN4O2 M.Wt 459.3
Solubility DMF: 2.5 mg/ml,DMSO: 1.5 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.1772 mL 10.8861 mL 21.7723 mL
5 mM 0.4354 mL 2.1772 mL 4.3545 mL
10 mM 0.2177 mL 1.0886 mL 2.1772 mL
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Review for CAY10561

Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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