Ciliobrevin D |
| Catalog No.GC39359 |
Ciliobrevin D est un inhibiteur perméable aux cellules, réversible et spécifique de la dynéine cytoplasmique motrice AAA+ ATPase. Ciliobrevin D inhibe la signalisation Hedgehog (Hh) et la formation de cils primaires. Ciliobrevin D inhibe le glissement des microtubules dépendant de la dynéine et l'activité ATPase in vitro.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1370554-01-0
Sample solution is provided at 25 µL, 10mM.
Ciliobrevin D is a cell-permeable, reversible and specific inhibitor of AAA+ ATPase motor cytoplasmic dynein. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation. Ciliobrevin D inhibits dynein-dependent microtubule gliding and ATPase activity in vitro[1][2].
[1]. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. [2]. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. [3]. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *