CP21 |
| Catalog No.GC48954 |
An iron chelator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30652-12-1
Sample solution is provided at 25 µL, 10mM.
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CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio.1 It is active against P. falciparum when used at concentrations of 10 and 100 µM.2 CP21 inhibits production of prostaglandin I2 induced by epinephrine, arachidonic acid , or A23187 in isolated rat aortic rings with IC50 values of 1.3, 1.3, and 1.4 mM, respectively.3 It inhibits glutamate-induced oxytosis, as well as decreases iodoacetic acid-induced cytotoxicity in an in vitro model of ischemia, in HT22 mouse hippocampal cells (EC50s = 13 and 9.5 µM, respectively).4 CP21 (200 mg/kg) increases the excretion of iron, but not copper, zinc, calcium, or magnesium, in rabbits.5
1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Heppner, D.G., Hallaway, P.E., Kontoghiorghes, G.J., et al.Antimalarial properties of orally active iron chelatorsBlood72(1)358-361(1988) 3.Jeremy, J.Y., Kontoghiorghes, G.J., Hoffbrand, A.V., et al.The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitroBiochem. J.254(1)239-244(1988) 4.Maher, P., and Kontoghiorghes, G.J.Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiproneNeurochem. Res.40(3)609-620(2015) 5.Kontoghiorghes, G.J., and Hoffbrand, A.V.Orally active α-ketohydroxy pyridine iron chelators intended for clinical use: In vivo studies in rabbitsBr. J. Haematol.62(4)607-613(1986)
| Cas No. | 30652-12-1 | SDF | |
| Canonical SMILES | O=C1C=CN(CC)C(C)=C1O | ||
| Formula | C8H11NO2 | M.Wt | 153.2 |
| Solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.5274 mL | 32.6371 mL | 65.2742 mL |
| 5 mM | 1.3055 mL | 6.5274 mL | 13.0548 mL |
| 10 mM | 652.7 μL | 3.2637 mL | 6.5274 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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