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D-α-Hydroxyglutaric Acid

Numéro de catalogue: GC18583

D-α ; - L'acide hydroxyglutarique ((R)-2-hydroxyglutarate) est le principal métabolite qui s'accumule dans la maladie neurométabolique D-2-hydroxyglutarique acidurie.

D-α-Hydroxyglutaric Acid Structure chimique

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49,00 $US
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D-α-Hydroxyglutaric acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2 (IDH2), causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

Propriétés chimiques

Cas No. 13095-47-1 SDF
Chemical Name 2R-hydroxy-pentanedioic acid
Canonical SMILES OC([C@@H](CCC(O)=O)O)=O
Formula C5H8O5 M.Wt 148.1
Solubilité 75mg/mL in Water (Need ultrasonic); Insoluble in DMSO Storage Store at -20°C
Conseils généraux Afin d'obtenir une solubilité plus élevée, veuillez chauffer le tube à 37 °C et le secouer dans le bain à ultrasons pendant un certain temps. La solution mère peut être conservée à une température inférieure à -20 °C pendant plusieurs mois.
Condition d'expédition Solution d'échantillon d'évaluation : livré avec la glace bleue
Toute autre taille disponible : livré avec RT ou la glace bleue sur demande

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