Accueil>>Signaling Pathways>> Proteases>> Drug Metabolite>>(E)-10-Hydroxynortriptyline

(E)-10-Hydroxynortriptyline (Synonyms: 10(E)-hydroxy Nortriptyline)

Catalog No.GC60399

La (E)-10-hydroxynortriptyline (E-10-OH-NT) est un métabolite de la nortriptyline.

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(E)-10-Hydroxynortriptyline Chemical Structure

Cas No.: 47132-16-1

Taille Prix Stock Qté
5mg
510,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

[1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

Chemical Properties

Cas No. 47132-16-1 SDF
Synonymes 10(E)-hydroxy Nortriptyline
Canonical SMILES OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC
Formula C19H21NO M.Wt 279.38
Solubility Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.5794 mL 17.8968 mL 35.7935 mL
5 mM 0.7159 mL 3.5794 mL 7.1587 mL
10 mM 0.3579 mL 1.7897 mL 3.5794 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for (E)-10-Hydroxynortriptyline

Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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