Accueil>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>> Akt>>(E)-Akt inhibitor-IV

(E)-Akt inhibitor-IV (Synonyms: (E)-AKTIV)

Catalog No.GC62122

L'inhibiteur de (E)-Akt-IV ((E)-AKTIV) est un inhibiteur de PI3K-Akt, avec un puissant cytotoxique.

Products are for research use only. Not for human use. We do not sell to patients.

(E)-Akt inhibitor-IV Chemical Structure

Cas No.: 959841-49-7

Taille Prix Stock Qté
5 mg
135,00 $US
En stock
10 mg
225,00 $US
En stock
25 mg
495,00 $US
En stock
50 mg
765,00 $US
En stock
100 mg
1 215,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic[1].

(E)-Akt inhibitor-IV (compound 7) exhibits average GI20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells)[1].(E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses[1].

[1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9.

Chemical Properties

Cas No. 959841-49-7 SDF
Synonymes (E)-AKTIV
Formula C31H27IN4S M.Wt 614.54
Solubility Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.6272 mL 8.1362 mL 16.2723 mL
5 mM 0.3254 mL 1.6272 mL 3.2545 mL
10 mM 0.1627 mL 0.8136 mL 1.6272 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for (E)-Akt inhibitor-IV

Average Rating: 5 ★★★★★ (Based on Reviews and 28 reference(s) in Google Scholar.)

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