(E/Z)-BCI (Synonyms: BCI, NSC 150117) |
| Catalog No.GC25000 |
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
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Cas No.: 15982-84-0
Sample solution is provided at 25 µL, 10mM.
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(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
[1] Jong-Woon Shin, et al. Sci China Life Sci. 2018 Oct;61(10):1243-1253. [2] Vasiliy N Korotchenko, et al. Chembiochem. 2014 Jul 7;15(10):1436-45.
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