(E/Z)-GO289 |
| Catalog No.GC62735 |
(E/Z)-GO289 est un inhibiteur puissant et sélectif de la caséine kinase 2 (CK2) (IC50 = 7 nM). (E/Z)-GO289 allonge fortement la période circadienne. (E/Z)-GO289 présente une inhibition dépendante du type de cellule de la croissance des cellules cancéreuses qui est corrélée avec la fonction de l'horloge cellulaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 694522-87-7
Sample solution is provided at 25 µL, 10mM.
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(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC50=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function[1].
(E/Z)-GO289 is a potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.(E/Z)-GO289 shows an IC50 of 13 μM for PIM2 and is >1000 times higher than that for CK2[1].(E/Z)-GO289 (3-9 μM; 2 days) strongly inhibits Caki-2, A498, and 769-P cells[1]. (E/Z)-GO289 enables manipulation of clock protein phosphorylation and cancer cell growth[1].
[1]. Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.
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