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(E/Z)-Zotiraciclib citrate (Synonyms: (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate)

Catalog No.GC64429

Le citrate de (E/Z)-zotiraciclib est un puissant inhibiteur de CDK2, JAK2 et FLT3.

Products are for research use only. Not for human use. We do not sell to patients.

(E/Z)-Zotiraciclib citrate Chemical Structure

Taille Prix Stock Qté
5 mg
99,00 $US
En stock
10 mg
135,00 $US
En stock
50 mg
405,00 $US
En stock
100 mg
585,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(E/Z)-Zotiraciclib citrate is a potent CDK2, JAK2, and FLT3 inhibitor[1].

[1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancer. J Med Chem. 2012;55(1):169-196.

Chemical Properties

Cas No. SDF Download SDF
Synonymes (E/Z)-TG02 citrate; (E/Z)-SB1317 citrate
Formula C29H32N4O8 M.Wt 564.59
Solubility DMSO : 250 mg/mL (442.80 mM; Need ultrasonic) Storage 4°C, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.7712 mL 8.856 mL 17.712 mL
5 mM 0.3542 mL 1.7712 mL 3.5424 mL
10 mM 0.1771 mL 0.8856 mL 1.7712 mL
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for (E/Z)-Zotiraciclib citrate

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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