Ecamsule disodium |
| Catalog No.GC61828 |
L'écamsule disodium est un filtre UVA à large spectre qui peut être utilisé dans les produits solaires.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 90458-75-6
Sample solution is provided at 25 µL, 10mM.
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Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression[1][2].
Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1].Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 µM) treatment. In the fibroblasts, Ecamsule counteractes UV and AAPH induced ROS-formation. In addition, basal ROS levels are reduced. The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 µM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%. Ecamsule increases the viability at the highest applied concentration of 1600 µM in the AAPH-treated cells[1].
References:
[1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2]. Vincent A DeLeo, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.
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