Endomorphin 1 (trifluoroacetate salt) (Synonyms: Tyr-Pro-Trp-Phe-NH2) |
| Catalog No.GC43602 |
Endomorphin 1 is an endogenous neuropeptide and μ-opioid receptor agonist (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Endomorphin 1 is an endogenous neuropeptide and μ-opioid receptor agonist (Ki = 0.36 nM) that has analgesic, positive reinforcing, and gastrointestinal properties. It is found in the brain and, to a lesser extent, in the spinal cord. It is selective for μ- over δ- and κ-opioid receptors (Ki = 1,506 and 5,428 nM, respectively). Endomorphin 1 also binds to mouse brain membranes and rat recombinant μ-opioid receptors expressed in CHO cells (Kis = 0.94 and 0.66 nM, respectively). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing rat recombinant μ-opioid receptors and in SH-SY5Y human neuroblastoma cells (IC50s = 9.33 and 19.1 nM, respectively). In mice, endomorphin 1 increases analgesia in a radiant heat tail-flick assay following intracerebroventricular or intrathecal administration (ED50s = 4.75 and 0.726 μg, respectively) and induces conditioned place preference when administered intracerebroventricularly at a dose of 10 μg. Endomorphin 1 (12 μg, i.c.v.) also decreases gastrointestinal transit time in mice.
| Cas No. | SDF | ||
| Synonymes | Tyr-Pro-Trp-Phe-NH2 | ||
| Canonical SMILES | O=C([C@H]1N(C([C@@H](N)CC2=CC=C(O)C=C2)=O)CCC1)N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)CC4=CNC5=C4C=CC=C5.FC(F)(C(O)=O)F | ||
| Formula | C34H38N6O5•XCF3COOH | M.Wt | 610.7 |
| Solubility | Formic Acid: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6375 mL | 8.1873 mL | 16.3747 mL |
| 5 mM | 327.5 μL | 1.6375 mL | 3.2749 mL |
| 10 mM | 163.7 μL | 818.7 μL | 1.6375 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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