(-)-FINO2
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| Catalog No.GC45248 |
(-)-FINO2 est un peroxyde organique qui peut induire sélectivement la ferroptose et qui est utilisé pour étudier les mécanismes de la ferroptose et les traitements anticancéreux.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 869298-31-7
Sample solution is provided at 25 µL, 10mM.
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(-)-FINO2 est un peroxyde organique qui peut induire sélectivement la ferroptose et qui est utilisé pour étudier les mécanismes de la ferroptose et les traitements anticancéreux[1]. (-)-FINO2 peut spécifiquement déclencher la peroxydation lipidique dépendante u fer en épuisant le glutathion et en inhibant l'activité de GPX4 pour induire la ferroptose[2]. (-)-FINO2 peut être employé pour examiner le rôle de la ferroptose dans des processus pathologiques tels que la suppression tumorale, les maladies neurodégénératives et les lésions d'ishémie-reperfusion[3-4].
In vitro, le traitement des chondrocytes articulaires humains (lignées cellulaires C-28/I2, T/C-28/A2 et chondrocytes primaires) avec (-)-FINO2 (20μM) pendant 24 heures réduit significativement la viabilité cellulaire en oxydant le Fe²⁺ instable et en inhibant indirectement l'activité de GPX4 pour déclencher la ferroptose[5]. Le traitement des cellules de fibrosarcome HT-1080 avec (-)-FINO2 (10μM) pendant 24 heures induit une mort cellulaire significative via un mécanisme de peroxydation lipidique dépendante du fer[6].
References:
[1] Abrams RP, Carroll WL, Woerpel KA. Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells. ACS Chem Biol. 2016 May 20;11(5):1305-12.
[2] Lei Y, Peng X, Hu Y, et al. The Calcilytic Drug Calhex-231 Ameliorates Vascular Hyporesponsiveness in Traumatic Hemorrhagic Shock by Inhibiting Oxidative Stress and miR-208a-Mediated Mitochondrial Fission. Oxid Med Cell Longev. 2020 Dec 3;2020:4132785.
[3] JHuang Y, Ru Q, Ruan H, et al. Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis. J Ethnopharmacol. 2025 Feb 27;342:119415.
[4] Van Kessel ATM, Cosa G. Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2317616121.
[5] Wipplinger A, Bekric D, Ablinger C, et al. Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. J Cell Mol Med. 2025 Jul;29(13):e70592.
[6] Gaschler MM, Andia AA, Liu H, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.
| Expériences cellulaires [1]: | |
Lignées cellulaires | Cellules de fibrosarcome HT-1080 (lignée cellulaire sensible à la ferroptose) |
Méthode de préparation | Les cellules HT-1080 ont été cultivées dans DMEM supplémenté avec 10% de sérum foetal bovin (SFB) à 37°C sous 5% de CO₂. Les cellules ont été traitées avec 10μM (-)-FINO2 for 6 or 24 hours. |
Conditions de réaction | 10μM; 6-24 heures |
Domaines d'application | (-)-FINO2 (10 μM) induit une mort cellulaire significative via un mécanisme de peroxydation lipidique dépendante du fer. |
References: | |
| Cas No. | 869298-31-7 | SDF | |
| Canonical SMILES | CC(C)(C)[C@@H](CC1)CC[C@]21CC(CCO)(C)OO2 | ||
| Formula | C15H28O3 | M.Wt | 256.4 |
| Solubility | 30 mg/ml in DMSO, 30 mg/ml DMF, 30 mg/ml in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.9002 mL | 19.5008 mL | 39.0016 mL |
| 5 mM | 780 μL | 3.9002 mL | 7.8003 mL |
| 10 mM | 390 μL | 1.9501 mL | 3.9002 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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