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(1S,3R,5R)-PIM447 dihydrochloride (Synonyms: (1S,3R,5R)-LGH447 dihydrochloride)

Catalog No.GC34964

Le (1S,3R,5R)-PIM447 (dichlorhydrate) un inhibiteur de PIM extrait du brevet US 20100056576 A1, exemple composé 72, a des valeurs d'IC50 de 0,095 μM pour Pim1, 0,522 μM pour Pim2 et 0,369 μM pour Pim3.

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(1S,3R,5R)-PIM447 dihydrochloride Chemical Structure

Taille Prix Stock Qté
10mM (in 1mL DMSO)
367,00 $US
En stock
1mg
130,00 $US
En stock
5mg
324,00 $US
En stock
10mg
464,00 $US
En stock
50mg
1 391,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. IC50: 0.095 μM (Pim1), 0.52 μM (Pim1), 0.369 μM (Pim1)

Chemical Properties

Cas No. SDF
Synonymes (1S,3R,5R)-LGH447 dihydrochloride
Canonical SMILES O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@@H]4C[C@H](N)C[C@H](C)C4)C=CN=C3.Cl.Cl
Formula C24H25Cl2F3N4O M.Wt 513.38
Solubility DMSO: 33.33 mg/mL (64.92 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.9479 mL 9.7394 mL 19.4787 mL
5 mM 0.3896 mL 1.9479 mL 3.8957 mL
10 mM 0.1948 mL 0.9739 mL 1.9479 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for (1S,3R,5R)-PIM447 dihydrochloride

Average Rating: 5 ★★★★★ (Based on Reviews and 29 reference(s) in Google Scholar.)

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