(S)-Ceralasertib (Synonyms: (S)-AZD6738) |
| Catalog No.GC34999 |
Le (S)-ceralasertib ((S)-AZD6738) est extrait du brevet WO2011154737A1, composé II, présente une IC50 de 2,578 nM.(S)-ceralasertib est un inhibiteur puissant et sélectif de la sulfoximine morpholinopyrimidine ATR avec d'excellentes propriétés physicochimiques et pharmacocinétiques précliniques (PK ) caractéristiques.(S)-Ceralasertib est développé pour améliorer la solubilité aqueuse et élimine l'inhibition dépendante du temps du CYP3A4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1352226-87-9
Sample solution is provided at 25 µL, 10mM.
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(S)-Ceralasertib is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM[1].(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition[2].
[1]. By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215. [2]. Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907.
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